CAVEPM Workshop 2019
The goal of this interactive workshop was to provide participants with an overview of the epidemiological and statistical methods necessary for carrying out a systematic review and meta-analysis of diagnostic accuracy. The workshop format included lectures followed by tutorials for a hands-on experience with the following software:
- R (from https://www.r-project.org/)
- RStudio (from https://www.rstudio.com/)
- JAGS (from https://sourceforge.net/projects/mcmc-jags/files/)
Session 1: Systematic Reviews of Diagnostic Accuracy
Session 2: Bivariate Meta-analyses
- Lecture
- Bivariate model (R Script, html output)
- HSROC model (R Script, html output)
- Examining heterogeneity (R Script, High Prev Data, Low Prev Data)
Session 3: Latent class meta-Analysis
- Single study latent class analysis
(Lecture, R Script, html output) - Latent class meta-analysis
(R Script, html output)
Session 4: Participant presentations
- Template for participant presentations
- Binax data set (see article by Sinclair et al. below)
- Lymph node TB dataset (see article by Kohli et al. below)
References
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Kohli M, Schiller I, Dendukuri N, Dheda K, Denkinger CM, Schumacher SG, Steingart KR. Xpert(®) MTB/RIF assay for extrapulmonary tuberculosis and rifampicin resistance. Cochrane Database Syst Rev. 2018 Aug 27;8:CD012768
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Sinclair A, Xie X, Teltscher M, Dendukuri N. Systematic review and meta-analysis of a urine-based pneumococcal antigen test for diagnosis of community-acquired pneumonia caused by Streptococcus pneumoniae. J Clin Microbiol. 2013 Jul;51(7):2303-10.
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Xie X, Sinclair A, Dendukuri N. Evaluating the accuracy and economic value of a new test in the absence of a perfect reference test. Res Synth Methods. 2017 Sep;8(3):321-332.
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