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Meta-analysis

Through my work in health technology assessment I have had the opportunity to work on a number of meta-analyses, both of randomized controlled trials and diagnostic test accuracy studies. 

Methods for meta-analysis

  • de Groot JA, Dendukuri N, Janssen KJ, Reitsma JB, Brophy J, Joseph L, Bossuyt PM, Moons KG. Adjusting for partial verification or workup bias in meta-analyses of diagnostic accuracy studies.  Am J Epidemiol. 2012 Apr 15;175(8):847-53.
  • Dendukuri N, Schiller I, Joseph L, Pai M. Bayesian meta-analysis of the accuracy of a test for tuberculous pleuritis in the absence of a gold standard reference. Biometrics. 2012 Dec;68(4):1285-93.
  • Zhou Y, Dendukuri N. Statistics for quantifying heterogeneity in univariate and bivariate meta-analyses of binary data: the case of meta-analyses of diagnostic accuracy. Stat Med. 2014 Jul 20;33(16):2701-17.

Applications of meta-analysis

  • Dendukuri N, Chiu K, Brophy JM. Validity of electron beam computed tomography for coronary artery disease: asystematic review and meta-analysis. BMC Med. 2007 
    Nov 25;5:35.
  • Steingart KR, Dendukuri N, Henry M, Schiller I, Nahid P, Hopewell PC, Ramsay A, Pai M, Laal S. Performance of purified antigens for serodiagnosis of pulmonary
    tuberculosis: a meta-analysis. Clin Vaccine Immunol. 2009 Feb;16(2):260-76.
  • Filion KB, El Khoury F, Bielinski M, Schiller I, Dendukuri N, Brophy JM. Omega-3 fatty acids in high-risk cardiovascular patients: a meta-analysis of
    randomized controlled trials. BMC Cardiovasc Disord. 2010 Jun 3;10:24.
  • Steingart KR, Flores LL, Dendukuri N, Schiller I, Laal S, Ramsay A, Hopewell PC, Pai M. Commercial serological tests for the diagnosis of active pulmonary and
    extrapulmonary tuberculosis: an updated systematic review and meta-analysis. PLoS Med. 2011 Aug;8(8):e1001062.
  • Flores LL, Steingart KR, Dendukuri N, Schiller I, Minion J, Pai M, Ramsay A, Henry M, Laal S. Systematic review and meta-analysis of antigen detection tests
    for the diagnosis of tuberculosis. Clin Vaccine Immunol. 2011 Oct;18(10):1616-27
  • Bally M, Dendukuri N, Sinclair A, Ahern SP, Poisson M, Brophy J. A network meta-analysis of antibiotics for treatment of hospitalised patients with suspected or 
    proven meticillin-resistant Staphylococcus aureus infection. Int J Antimicrob Agents. 2012 Dec;40(6):479-95.
  • Steingart KR, Sohn H, Schiller I, Kloda LA, Boehme CC, Pai M, Dendukuri N. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in
    adults. Cochrane Database Syst Rev. 2013 Jan 31;1:CD009593.
  • Sinclair A, Xie X, Teltscher M, Dendukuri N. Systematic review and meta-analysis of a urine-based pneumococcal antigen test for diagnosis of
    community-acquired pneumonia caused by Streptococcus pneumoniae. J Clin Microbiol. 2013 Jul;51(7):2303-10.
  • Steingart KR, Schiller I, Horne DJ, Pai M, Boehme CC, Dendukuri N. Xpert® MTB/RIF assay for pulmonary tuberculosis and rifampicin resistance in adults.
    Cochrane Database Syst Rev. 2014 Jan 21;1:CD009593.
  • Denkinger CM, Schumacher SG, Boehme CC, Dendukuri N, Pai M, Steingart KR. Xpert MTB/RIF assay for the diagnosis of extrapulmonary tuberculosis: a
    systematic review and meta-analysis. Eur Respir J. 2014 Aug;44(2):435-46.
  • Detjen AK, DiNardo AR, Leyden J, Steingart KR, Menzies D, Schiller I, Dendukuri N, Mandalakas AM. Xpert MTB/RIF assay for the diagnosis of pulmonary
    tuberculosis in children: a systematic review and meta-analysis. Lancet Respir Med. 2015 Jun;3(6):451-61.